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Biblioteca de Investigación Cognitive & Neurological
Cognitive & Neurological

Selank

A synthetic heptapeptide derived from the immune compound tuftsin, studied for its simultaneous influence on anxiety-related pathways and cognitive function.

También conocido como TP-7
Tipo Heptapeptide
Área de Investigación Anxiolysis, Cognition, Immune Modulation
Status Solo para Investigación
Molecular structure of Selank — animated Molecular structure of Selank
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3D Animated Structure
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What is it?

Selank is a synthetic peptide derived from tuftsin, a naturally occurring immune-modulating compound produced by the body. Investigacióners developed it by combining a tuftsin fragment with a stabilizing peptide sequence to improve its durability and bioavailability. The result is a short, 7-amino-acid chain that has been studied primarily in Russian research institutions for decades.

It's one of a genuinely unusual family of peptides that appear to influence both brain function and immune activity simultaneously — a combination that makes it particularly interesting to researchers studying the intersection of neuroscience and immunology.

Por qué interesa a los investigadores

Selank sits at an interesting crossroads — it's been studied for calming effects alongside cognitive metrics, rather than one or the other. That dual research angle is relatively rare in this category of compounds.

  • Studied for its potential influence on GABA-A receptor activity — the same system targeted by many commonly studied calming agents
  • Investigación has explored its effects on BDNF (Brain-Derived Neurotrophic Factor), a protein that plays a key role in neuron growth and learning
  • Unlike many compounds studied for anxiolytic properties, Selank has been examined for memory and cognitive function simultaneously
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How It Works

Selank is thought to interact with the GABAergic system — the brain's primary inhibitory network — and may also influence enkephalin breakdown. Enkephalins are endogenous peptides the brain uses to regulate pain and mood, and their duration of activity is controlled partly by enzymes that break them down quickly.

Think of it like this 🧠

Think of the brain as a really busy office. Enkephalins are like those "do not disturb" signs people hang on their doors when they need to focus. Selank may work like a security guard who stops people from taking those signs down too quickly — so the "do not disturb" signal lasts longer, and more calm gets through.

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Contexto de Protocolo de Investigación

Investigación Renuncia de responsabilidad: Lo siguiente refleja investigación clínica y preclínica publicada y no es consejo médico. Consulta a un profesional de la salud licenciado antes de tomar decisiones de salud.

Selank is registered as a pharmaceutical in Russia (0.15% nasal spray) for anxiety and cognitive disorders. Published clinical data comes primarily from Russian institutions and is documented in the Russian pharmacological literature.

Dosing Ranges from Published Investigación
Russian Clinical Approved nasal spray delivers 50–200 µg per nostril per administration. Semenova et al. (2009, Bull Exp Biol Med) reported clinical protocols using 2–3 intranasal administrations daily (100 µg/nostril = 200 µg/dose) over 10–14 day courses for anxiety and generalized anxiety disorder.
Preclínico (Roedor) Rodent anxiety (EPM, open field) and cognitive studies used 50–300 µg/kg IP or SC. CNS effects documented within 20–30 minutes of administration in behavioral assays (Zozulya et al., 2006, CNS Drug Rev).
Routes, Duration & Timing
IntranasalPrimary route for CNS delivery via olfactory pathway. Nasal administration provides rapid CNS access. Short half-life (~5 minutes) makes the nasal route practical for multiple daily administrations.
TimelineAnxiolytic effects in published clinical studies observed within the first week. Cognitive endpoint improvements measured at end of 10-14 day course.
ReconstitutionSupplied as lyophilized powder; nasal formulation is aqueous solution. Store at 4°C after preparation; lyophilized at −20°C.

Referencias Clave: Semenova TP et al. (2009). Selank anxiolytic effects. Bull Exp Biol Med. · Zozulya AA et al. (2006). Selank pharmacology review. CNS Drug Rev. · Uchakina ON et al. (2008). Selank immunomodulation. Bull Exp Biol Med.

Datos Interesantes

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Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences — it has been studied in Russian labs since the 1990s and remains one of the most researched peptides from that era.

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It's derived from tuftsin, a peptide your own immune system produces naturally. Investigacióners took that existing biological structure and engineered it further — giving Selank a foot in both the immune and neurological worlds.

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In some published studies, Selank has been examined alongside learning tasks — researchers have directly measured its effects on memory retrieval speed in laboratory settings, not just general mood or calm.

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Documentación COA y de Lotes

Every batch of Selank with full Certificate of Analysis documentation. Third-party HPLC verification, mass spectrometry confirmation, and sterility testing results are included with each batch.

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HPLC Certificate
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Mass Spec Analysis
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Purity Report
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Sterility Test
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